fluconazole dosage for candida overgrowth

The creams and suppositories in these regimens are oil based and might weaken latex condoms and diaphragms.

Treatment with azoles results in relief of symptoms and negative cultures in 80%–90% of patients who complete therapy. Short-course topical formulations (i.e., single dose and regimens of 1–3 days) effectively treat uncomplicated VVC. Yeast culture, which can identify a broad group of pathogenic yeasts, remains the reference standard for diagnosis. The majority of PCR tests for yeast are not FDA cleared, and providers who use these tests should be familiar with the performance characteristics of the specific test used. Identifying Candida by culture in the absence of symptoms or signs is not an indication for treatment because approximately 10%–20% of women harbor Candida species and other yeasts in the vagina. If Candida cultures cannot be performed for these women, empiric treatment can be considered. For those with negative wet mounts but existing signs or symptoms, vaginal cultures for Candida should be considered. Examination of a wet mount with KOH preparation should be performed for all women with symptoms or signs of VVC, and women with a positive result should be treated.

Use of 10% KOH in wet preparations improves the visualization of yeast and mycelia by disrupting cellular material that might obscure the yeast or pseudohyphae. Candida vaginitis is associated with normal vaginal pH (<4.5). The diagnosis can be made in a woman who has signs and symptoms of vaginitis when either a wet preparation (saline, 10% KOH) of vaginal discharge demonstrates budding yeasts, hyphae, or pseudohyphae, or a culture or other test yields a positive result for a yeast species. Most healthy women with uncomplicated VVC have no identifiable precipitating factors. Signs include vulvar edema, fissures, excoriations, and thick curdy vaginal discharge. Uncomplicated Vulvovaginal Candidiasis Diagnostic ConsiderationsĪ diagnosis of Candida vaginitis is clinically indicated by the presence of external dysuria and vulvar pruritus, pain, swelling, and redness.

Fluconazole dosage for candida overgrowth